There's a reason that fluffy sofa is called a La-Z-Boy. There's also a reason why sitting on it may land you a similar appellation.

Researchers from the University of Missouri found that sitting down too often causes the shutdown of an enzyme that prevents fat storage. According to the study author, who was interviewed in Men's Health magazine, "The enzyme is mostly found in the muscles that keep you standing up, so if they aren't active, it doesn't function."

Couple this with the fact that we burn far less calories while sitting when we do standing up, and I'm sure you'll suddenly feel the urge to jump to your feet.

Source

Here's something that's probably the last thing you want to read right now, considering that you're likely sitting down at this very moment: Researchers from the University of Missouri claim that sitting down shuts down your body's natural fat burning properties.

To arrive at these findings, the researchers took a close look at a particular enzyme that prevents fat storage. They discovered that it was far less functional in people who were inactive, which may be a contributing factor to weight gain. The enzyme is found in the muscles used when a person is standing, something that does not bode well for people who spend most of their day on their butts.

To help keep this enzyme active and functioning properly, be sure to get out of your seat and take a short walk (around your office or wherever else) every so often. Not only will it help keep the fat burning switch on, but it will also help prevent against such circulatory issues as DVT.

Source