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A Weight-Loss Drug That Can Reverse Diabetes Too?

Posted on Aug 31st 2009 4:00PM by Martha Edwards
Filed Under: Diet & Weight Loss
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Photo: Darren Hester, Flickr
Some weight loss drugs help you slim down but may cost you your health -- and other products don't even work at all. But there is some promise in a new drug in development that can not only help you lose weight, but can also help treat serious complications of obesity, specifically diabetes and high cholesterol. In recent studies on mice, fatostatin, as it is currently known, led to weight loss of 12 percent, reduction in blood sugar levels of 70 percent, reversal of diabetes and lower cholesterol. According to the findings from Chemistry & Biology, "Fatostatin blocked increases in body weight, blood glucose, and hepatic (liver) fat accumulation in (genetically) obese mice, even under uncontrolled food intake."

As for how it works? In a nutshell, Fatostatin stops the body from producing fat -- it's released as energy instead. It works by effectively 'turning off' proteins that help control fat synthesis.

OK, it's one thing to help mice lose weight -- past experience has proved that what works on a mouse doesn't always work on a human. So can it do the same for us? "I am very, very optimistic," lead author Sahil Wakil tells MSNBC. So are we -- but I'm hoping most of us are taking steps to change our lives today instead of holding out for a so-called miracle drug that's years away.

Wondering how to slim down? Find out how Phylicia Rashad did it.

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