Whether or not you're the kind of guy who admits to watching Oprah, you might just want to tune in on Monday. For the first time in the show's 22 years, Oprah will step off the stage and leave Dr. Oz and the men-only audience on their own to discuss men's health. The 300-man audience includes a handful of sports superstars, and promises to answer men's most embarrassing questions.

The queen of daytime talk shows is never far away, however. Oprah's in the back room listening in with her own audience full of women. Dr. Oz is usually full of interesting health information, so hopefully there's something to learn from this entertaining episode.