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Some drugs could turn toxic in obese patients

Posted: Mar 6th 2007 5:00PM by Bethany Sanders
Filed under: General Health, Healthy Habits, Diet and Weight Loss, HealthWatch, Healthy Products and Reviews

Being overweight to the point of obesity can cause a host of health problems: type II diabetes, increased risk of heart disease, joint problems, etc. But did you know that being obese can also affect how your body handles certain medications and in some cases even make them toxic?

The root of the problem seems to be in the liver. When a person becomes obese, liver enzymes often change due to increased fat in the organ's cells. This changes the way the liver metabolizes some medications and can make them dangerous. Though two of the three medications mentioned in this article are not commonly used (one is a powerful antibiotic only used in hospitals and the other is a diuretic), acetaminophen, a common pain reliever, is one of the drugs experts are worried about.

I was surprised to learn that half of the liver transplants that take place in America are necessary because of acetaminophen poisoning leading to liver failure. That means that people with obesity whose livers are affected could be at risk of acetaminophen toxicity if they take the drug in large doses.

The good news is that losing weight protects not only your heart, but all of your organs, including your liver. One more reason to choose well when you're planning your meals today!


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